CML
Awareness Alert: Chronic Myeloid Leukemia
- Join me in spreading awareness about Chronic Myeloid Leukemia (CML), a rare but manageable blood cancer. 🌟 CML might be a challenge, but with the right treatment and support, we can overcome it.
- Let's share information, stories of strength, and resources to empower those facing CML. 🩹 Knowledge is power - Learn about the latest treatments and support available.
- Let's share information, stories of strength, and resources to empower those facing CML. 🩹 Knowledge is power - Learn about the latest treatments and support available.
#CMLAwareness #StrengthInNumbers #CancerWarrior #hematologistinmumbai #hematologistinborivali #hematologistinvirar #hematologistinandheri #hematologistingoregaon
What Is Cancer?
Cancer starts when cells in the body start to grow out of control. Cells in nearly any part of the body can become cancer, and can spread to other parts of the body. To learn more about how cancers start and spread, see.
- Cancer starts when cells in the body start to grow out of control. Cells in nearly any part of the body can become cancer, and can spread to other parts of the body. To learn more about how cancers start and spread, see
- It's a type of cancer that starts in certain blood-forming cells of the bone marrow.
- In CML, a genetic change takes place in an early (immature) version of myeloid cells -- the cells that make red blood cells, platelets, and most types of white blood cells (except lymphocytes).
- This change forms an abnormal gene called BCR-ABL, which turns the cell into a CML cell.
- The leukemia cells grow and divide, building up in the bone marrow and spilling over into the blood.
- In time, the cells can also settle in other parts of the body, including the spleen.
- CML is a fairly slow growing leukemia, but it can change into a fast-growing acute leukemia that's hard to treat.
- CML occurs mostly in adults, but very rarely it occurs in children, too. In general, their treatment is the same as for adults.
- CML accounts for approximately 15 to 20 percent of leukemias in adults.
- It has an annual incidence of 1 to 2 cases per 100,000, with a slight male predominance.
- The median age at presentation is approximately 50 years for patients enrolled on clinical studies, but the actual median age from cancer registry data may be 10 years older.
- Exposure to ionizing radiation is the only known risk factor.
- While there is no known familial disposition to CML rare families in which multiple members develop myeloproliferative neoplasms (MPNs), including CML, have been described.
- Studies of these families suggest the presence of an autosomal dominant mutation that may predispose to acquisition of a secondary somatic mutation such as the Philadelphia chromosome translocation or JAK2 mutation.
- It is unknown whether specific genetic variants predispose persons in the general population to develop CML.
- However, a genome-wide association study of Korean and European cohorts suggested that persons with genetic variants at two chromosomal loci, 6q25.1 and 17p11.1, may be more likely to develop CML.
Chronic myelogenous leukemia often doesn't cause symptoms.
It might be detected during a blood test. When they occur, symptoms may include:
- Bone pain.
- Bleeding easily.
- Bleeding easily.
- Fatigue.
- Fever.
- Weight loss without trying.
- Loss of appetite.
- Pain or fullness below the ribs on the left side.
- Excessive sweating during sleep.
- Blurry vision caused by bleeding in the back of the eye
- Chronic myeloid leukemia (CML) can be treated through various methods, including targeted therapy with tyrosine kinase inhibitors (TKIs), such as imatinib, dasatinib, and nilotinib.
- These medications are often the first line of treatment, effectively controlling the growth of leukemic cells.
- These medications are often the first line of treatment, effectively controlling the growth of leukemic cells.
- Treatment plans should be discussed with a hematologist as they can provide personalized guidance based on the specific characteristics of the disease and the patient's overall health.
DR SURAJ CHIRANIYA AND TEAM IS KNOWN FOR MANAGING CHRONIC MYELOID LEUKEMIA IN INDIA .