Hemophilia Happens
How and Why Hemophilia Happens?
- Hemophilia is a genetic disorder, so its primary cause is a mutation in one of the genes responsible for producing clotting factors in the blood.
- There are two main types of hemophilia:
- Hemophilia A: Hemophilia A is caused by a deficiency of clotting factor VIII (FVIII).
- This deficiency results from mutations in the F8 gene located on the X chromosome.
- Hemophilia A is inherited in an X-linked recessive manner, meaning that the defective gene is carried on the X chromosome.
- Males are more commonly affected by hemophilia A because they have only one X chromosome and, if it carries the mutation, they will have the condition.
- Females, who have two X chromosomes, can be carriers of the hemophilia gene but are less likely to exhibit symptoms.
- Hemophilia B: Hemophilia B is caused by a deficiency of clotting factor IX (FIX).
- This deficiency results from mutations in the F9 gene, also located on the X chromosome.
- Like hemophilia A, hemophilia B is inherited in an X-linked recessive manner.
- In both types of hemophilia, the lack of these clotting factors impairs the blood's ability to clot properly, leading to prolonged bleeding.
- The severity of hemophilia can vary depending on the specific mutation and the amount of clotting factor that is produced.
- It's important to note that hemophilia is a genetic condition, and individuals with a family history of hemophilia are at a higher risk of being affected by the disorder.
- Genetic testing and counseling can help families understand their risk and make informed decisions.
Hemophilia cannot be caused by external factors, as it is a result of an inherited genetic mutation.