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Hemophilia Happens

How and Why Hemophilia Happens?

  • Hemophilia is a genetic disorder, so its primary cause is a mutation in one of the genes responsible for producing clotting factors in the blood.
  • There are two main types of hemophilia:
  • Hemophilia A: Hemophilia A is caused by a deficiency of clotting factor VIII (FVIII).
  • This deficiency results from mutations in the F8 gene located on the X chromosome.
  • Hemophilia A is inherited in an X-linked recessive manner, meaning that the defective gene is carried on the X chromosome.
  • Males are more commonly affected by hemophilia A because they have only one X chromosome and, if it carries the mutation, they will have the condition.
  • Females, who have two X chromosomes, can be carriers of the hemophilia gene but are less likely to exhibit symptoms.
  • Hemophilia B: Hemophilia B is caused by a deficiency of clotting factor IX (FIX).
  • This deficiency results from mutations in the F9 gene, also located on the X chromosome.
  • Like hemophilia A, hemophilia B is inherited in an X-linked recessive manner.
  • In both types of hemophilia, the lack of these clotting factors impairs the blood's ability to clot properly, leading to prolonged bleeding.
  • The severity of hemophilia can vary depending on the specific mutation and the amount of clotting factor that is produced.
  • It's important to note that hemophilia is a genetic condition, and individuals with a family history of hemophilia are at a higher risk of being affected by the disorder.
  • Genetic testing and counseling can help families understand their risk and make informed decisions.

Hemophilia cannot be caused by external factors, as it is a result of an inherited genetic mutation.