Thrombocytosis
What Is Thrombocytosis ?
- Thrombocytosis – Thrombocytosis is defined as a platelet count >450,000/microL (>450 x 109/L) in adults and children
What Are The Causes Of Thrombocytosis ?
Causes – Thrombocytosis can be caused by:
- Reactive processes – Platelet counts increase with iron deficiency, splenectomy, and in response to infectious, inflammatory, or malignant conditions.
- Autonomous processes – Essential thrombocythemia, polycythemia vera, and other myeloproliferative neoplasms cause unregulated, clonal proliferation of hematopoietic stem and progenitor cells.
How Is The Patient With Thrombocytosis Evaluated ?
- Laboratory
- Complete blood count (CBC)
- Blood smear
- Serum ferritin
History of bleeding, thrombosis, vasomotor symptoms (eg, erythromelalgia, flushing, pruritus), constitutional symptoms (eg, unexplained fever, sweats, or weight loss), iron deficiency anemia, and examination for splenomegaly
The treatment of thrombocytosis depends on its underlying cause and whether it is primary (essential) or secondary (reactive) thrombocytosis.
Here are some general guidelines for managing thrombocytosis:
Secondary Thrombocytosis (Reactive Thrombocytosis):
- Secondary thrombocytosis is usually a response to an underlying condition.
- Treatment primarily involves addressing the root cause. Here's how to manage it:
Treat the Underlying Condition: Work with your HEMATOLOGIST to identify and treat the primary cause, which could be an
- Infection
- Inflammation
- Surgery
- Anemia
- Certain Medications.
Regular Monitoring: Your HEMAROLOGIST will monitor your platelet count to ensure that it returns to a normal range once the underlying condition is resolved.
Primary Thrombocytosis (Essential Thrombocytosis):
- Primary thrombocytosis is associated with bone marrow disorders and requires more specialized treatment:
- Low-Dose Aspirin: In some cases, low-dose aspirin may be prescribed to reduce the risk of blood clot formation.
- Cytoreduction: Medications like hydroxyurea or anagrelide may be recommended to lower platelet counts in individuals with primary thrombocytosis and a high risk of blood clot formation under supervision of HEMATOLOGIST
- Regular Monitoring: Ongoing monitoring of platelet counts and overall health is essential to assess the effectiveness of treatment and adjust it as needed.
- Platelet Apheresis: In extreme cases with very high platelet counts and severe symptoms, platelet apheresis (a medical procedure to reduce platelet levels) may be used temporarily.
It's crucial to work closely with a hematologist or healthcare provider to determine the cause of thrombocytosis and develop a personalized treatment plan. The treatment approach will be tailored to the specific circumstances of the patient and the severity of the condition.
DR.SURAJ AND HIS TEAM IS KNOWN TO DO ALL TYPES OF BONE MARROW TRANSPLANTS LIKE AUTOLOGOUS ALLOGENIC MATCH UNRELATED DONOR HAPLOIDENTICAL TRANSPLANT ANDALL CASES OF THROMBOCYTOSIS.